Daily Page: 2025-12-14
Mechanisms of Action of What, Precisely?
It is what it is and what it is, is more affirmation.
Almost as if … even more overwhelming empirical reality.
What if a simple breath could rewrite your mind’s story?
— Innertune Affirmations (@InnertuneApp) December 14, 2025
Science shows your breath connects your conscious and subconscious, influencing 95% of your daily actions.
Lets explore how this works 🧵 pic.x.com/BK0EIHT4Tj
Mechanisms of Action of What, Precisely?
It is what it is and what it is, is more affirmation.
Mechanisms of Action of What, Precisely?
It is what it is and what it is, is more affirmation.
Generative Optogenetics Proposers Workshop
Active Contract Opportunity
Notice ID DARPA-SN-26-19
Related Notice Department/Ind. Agency
DEPT OF DEFENSE
Sub-tier DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA)
Office DEF ADVANCED RESEARCH PROJECTS AGCY
General Information
- Contract Opportunity Type: Special Notice (Original)
- Original Published Date: Dec 09, 2025 09:17 am EST
- Original Response Date: Jan 05, 2026 11:59 pm EST
- Inactive Policy: Manual
- Original Inactive Date: Jan 10, 2026
- Initiative:
- None
Classification
- Original Set Aside:
- Product Service Code: AC12 - NATIONAL DEFENSE R&D SERVICES; DEPARTMENT OF DEFENSE - MILITARY; APPLIED RESEARCH
- NAICS Code:
- 541714 - Research and Development in Biotechnology (except Nanobiotechnology)
- Place of Performance:
Description
The Biological Technologies Office (BTO) of the Defense Advanced Research Projects Agency (DARPA) is hosting a Proposer’s Workshop in support of an anticipated Program Solicitation (PS) for the Generative Optogenetics (GO) program. The Proposers Workshop will be held on Wednesday, January 7, 2026, in the Greater DC area (specific venue location to be announced on the registration website). Advance registration is required. Registrants will have the opportunity to provide teaming profiles and give a lightening talk. There are a limited number of timeslots for lightening talks, so they must be scheduled upon registration on a first come first served basis. Note, all times listed in this announcement and on the registration website are Eastern Time.
Contact Information
Contracting Office Address
- 675 NORTH RANDOLPH STREET
- ARLINGTON , VA 222032114
- USA
Primary Point of Contact
- Dr. Matthew J. Pava
- GO@darpa.mil
Mechanisms of Action of What, Precisely?
It is what it is and what it is, is more affirmation.
Mechanisms of Action of What, Precisely?
It is what it is and what it is, is more affirmation.
Paper: Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks
“A neuroscience paper published in Cell just days ago answers a question researchers have been trying to solve for years: what actually changes in the brain during a psilocybin experience—and why those changes can last.”
“Using a genetically modified rabies virus as a neural tracer, researchers were able to map—cell by cell—how psilocybin alters brain connectivity. This allowed them to see, for the first time, which brain regions gain connections, which lose them, and how those changes depend on what the brain is doing during the experience itself.”
The findings help explain long-standing observations discussed by neuroscientists, psychiatrists, and researchers often referenced on platforms like Huberman Lab:
• Why psilocybin can reduce depression and anxiety
• Why the default mode network quiets during psychedelic states
• Why sensory perception feels intensified
• Why context and mental state during a trip matter so much
• Why a single experience can lead to lasting psychological changeOne of the most important results from the study is this: only brain regions that are active during the psilocybin experience undergo lasting rewiring. Inactive regions do not change.
That finding has major implications for mental health treatment, psychotherapy, and our understanding of how perception, mood, and identity are shaped at the neural level.
In this video, I walk through:
• How the rabies tracer virus works and why it was used
• What changed in sensory, emotional, and self-referential brain networks
• How this relates to depression, anxiety, PTSD, and trauma
• What this discovery means for future psychedelic research.— Chase Hughes
Mechanisms of Action of What, Precisely?
It is what it is and what it is, is more affirmation.
Seems Like it Kind of Depends Upon Which So-Called Present Order One is Presently Perceiving and Experiencing via Your INESCAPABLY SUBJECTIVE So-Called Objective Inquiry, isn’t it?
Almost as if Eternal Reference Frame is Eternal Reference Frame.
A frame of reference is a frame of reference.
As a physical metaphor, might as well argue for or against the validity of color blindness or any other sensorimotor distinction. What’s the point? “I was born without legs,” isn’t a debate of “just your subjective experience, man,” for the one so born. What’s the point of arguing the efficacy of legs with such a one? Ignorance, at best. Cruelty is far more common among poo-flinging chimpanzees, alas. May God grant more and more humans the breadth of intellectually honest curiosity of Saint Kuhn, and the patience and plain speech of Saint Swinburne.
On the Instantaneous Eternal Incineration-Animation of the Simultaneous Immeasurably Small Inexplicably Omnipotent Planck-pixel. Maybe. Works if all the energy information of all the cosmos is encoded in every holographic rulial shard; per early 21st century scientific concurrence.
What if every Planck-pixel contains the entirety of the hologram; because that’s ‘just’ how holograms work?
Given:
Falsify:
What is Profoundly Right and True?
— Rob Cunningham | KUWL.show (@KuwlShow) December 13, 2025
Jesus was not speaking in ego, exclusivity, or narcissistic self-worship when He said
“I AM.”
He was revealing identity alignment, not personal supremacy.
Scripture confirms this repeatedly:
“The Kingdom of God is within you.” (Luke 17:21)… pic.x.com/SeHmQNsgnN
